Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL657559 | 0.99 | PRKCZ (0.64) | PRKCZTDP1PNPKDM4ERAB9A | |
| SCHEMBL2304297 | 0.93 | PRKCZ (0.68) | PRKCZKDM4ERAB9APIN1PRKAG1 | |
| Hydrochloric Acid SCHEMBL657315 | 0.92 | PRKCZ (0.67) | PRKCZKDM4ERAB9APIN1PRKAG1 | |
| SCHEMBL2302390 | 0.91 | PRKCZ (0.66) | PRKCZPNPPIN1PRKAG1PRKAA2 | |
| SCHEMBL2302726 | 0.91 | PRKCZ (0.78) | PRKCZTDP1RAB9APIN1 | |
| Hydrochloric Acid SCHEMBL657205 | 0.91 | PRKCZ (0.65) | PRKCZPNPKDM4ERAB9APIN1 | |
| SCHEMBL659483 | 0.90 | PRKCZ (0.72) | PRKCZTDP1KDM4ERAB9APIN1 | |
| Hydrochloric Acid SCHEMBL657199 | 0.88 | PRKCZ (0.71) | PRKCZTDP1KDM4ERAB9APIN1 | |
| SCHEMBL2303594 | 0.88 | PRKCZ (0.64) | PRKCZKDM4ERAB9APIN1 | |
| SCHEMBL2303912 | 0.88 | PRKCZ (0.84) | PRKCZTDP1KDM4ERAB9APIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |