Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.63 |
| ▸ | FNTA | P49354 | 2/20 | 0.47 |
| ▸ | FNTB | P49356 | 2/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL658158 | 0.99 | PRKCZ (0.62) | PRKCZFNTAFNTBGABBR2GABBR1 | |
| SCHEMBL2303038 | 0.92 | PRKCZ (0.72) | PRKCZFNTAFNTBCYP2C9CYP3A4 | |
| SCHEMBL659483 | 0.88 | PRKCZ (0.72) | PRKCZGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL659145 | 0.88 | PRKCZ (0.64) | PRKCZFNTAFNTBKDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL658866 | 0.87 | PRKCZ (0.63) | PRKCZFNTAFNTBKDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL657199 | 0.87 | PRKCZ (0.71) | PRKCZGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL657599 | 0.86 | PRKCZ (0.67) | PRKCZFNTAFNTBGABBR2GABBR1 | |
| SCHEMBL2305619 | 0.86 | PRKCZ (0.61) | PRKCZGABBR2GABBR1LMNACYP2C9 | |
| Hydrochloric Acid SCHEMBL658126 | 0.85 | PRKCZ (0.66) | PRKCZFNTAFNTBGABBR2GABBR1 | |
| Hydrochloric Acid SCHEMBL657382 | 0.85 | PRKCZ (0.60) | PRKCZGABBR2GABBR1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |