Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CDK11B | P21127 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360645 | 0.83 | SRC (1.00) | SRCEGFRABL1FYNLCK | |
| SCHEMBL31061171 | 0.83 | SRC (1.00) | SRCEGFRABL1FYNLCK | |
| SCHEMBL22364024 | 0.80 | SRC (0.82) | SRCEGFRAURKBABL1FYN | |
| SCHEMBL19683595 | 0.79 | FLT3 (0.70) | RIPK1BTKLCKCSF1RRET | |
| SCHEMBL14693459 | 0.77 | SRC (0.62) | SRCEGFRABL1FYNBTK | |
| SCHEMBL19683865 | 0.77 | SRC (0.52) | SRCEGFRAURKAIKBKEAURKB | |
| SCHEMBL13063877 | 0.75 | SRC (0.82) | SRCEGFRAURKBABL1FYN | |
| SCHEMBL13019674 | 0.75 | SRC (1.00) | SRCEGFRABL1FYNBTK | |
| SCHEMBL19683619 | 0.73 | SRC (0.56) | SRCEGFRAURKAIKBKEAURKB | |
| SCHEMBL14693469 | 0.73 | SRC (0.54) | SRCEGFRAURKAIKBKEAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |