Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.82 |
| ▸ | EGFR | P00533 | 2/20 | 0.82 |
| ▸ | ABL1 | P00519 | 3/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.57 |
| ▸ | YES1 | P07947 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13063877 | 0.95 | SRC (0.82) | SRCEGFRABL1CCNA2CDK2 | |
| SCHEMBL2360645 | 0.90 | SRC (1.00) | SRCEGFRABL1CCNA2CDK2 | |
| SCHEMBL31061171 | 0.90 | SRC (1.00) | SRCEGFRABL1CCNA2CDK2 | |
| SCHEMBL25068862 | 0.90 | NUDT14 (0.68) | SRCEGFRABL1CCNA2CDK2 | |
| SCHEMBL3784286 | 0.82 | SRC (0.61) | SRCEGFRABL1FYNKDM4E | |
| SCHEMBL13019674 | 0.82 | SRC (1.00) | SRCEGFRABL1CCNA2CDK2 | |
| SCHEMBL14574734 | 0.81 | SRC (0.60) | SRCEGFRABL1CCNA2CDK2 | |
| SCHEMBL23035193 | 0.80 | SRC (0.70) | SRCEGFRABL1FYNKDM4E | |
| SCHEMBL13840179 | 0.79 | PIK3CD (0.71) | SRCEGFRABL1FYNKDM4E | |
| SCHEMBL409367 | 0.77 | PIK3CD (0.82) | SRCEGFRABL1FYNKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48175-E1 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-08-25 | — | — | US | disclosed |