Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.79 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL657365 | 0.99 | PRKCZ (0.77) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| SCHEMBL2301688 | 0.95 | PRKCZ (0.84) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| Hydrochloric Acid SCHEMBL655850 | 0.94 | PRKCZ (0.83) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| SCHEMBL2304297 | 0.93 | PRKCZ (0.68) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| Hydrochloric Acid SCHEMBL657315 | 0.92 | PRKCZ (0.67) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| SCHEMBL659483 | 0.92 | PRKCZ (0.72) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| SCHEMBL655698 | 0.92 | PRKCZ (0.67) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| SCHEMBL2303682 | 0.91 | PRKCZ (0.90) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| Hydrochloric Acid SCHEMBL657199 | 0.91 | PRKCZ (0.71) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E | |
| SCHEMBL2301693 | 0.88 | PRKCZ (1.00) | PRKCZPRKAG1PRKAA2PRKAB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |