Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 12/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 10/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23037401 | 1.00 | NTRK1 (0.51) | NTRK1NTRK3NTRK2JAK2CSNK2A2 | |
| SCHEMBL31171167 | 1.00 | NTRK1 (0.51) | NTRK1NTRK3NTRK2JAK2CSNK2A2 | |
| SCHEMBL29617203 | 0.92 | NTRK1 (0.51) | NTRK1NTRK3NTRK2JAK2 | |
| SCHEMBL23037390 | 0.81 | NTRK1 (0.59) | NTRK1NTRK3NTRK2 | |
| SCHEMBL31171166 | 0.81 | NTRK1 (0.59) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23037392 | 0.81 | NTRK1 (0.59) | NTRK1NTRK3NTRK2 | |
| SCHEMBL30688867 | 0.78 | NTRK1 (0.44) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16946775 | 0.77 | NTRK1 (0.53) | NTRK1NTRK3NTRK2 | |
| SCHEMBL30092503 | 0.77 | NTRK1 (0.53) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16947001 | 0.76 | IRAK4 (0.42) | NTRK1NTRK3NTRK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3786167-B1 | DIARYL MACROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF | PRIMEGENE BEIJING CO LTD (CN) | 2024-08-21 | — | — | EP | disclosed |
| EP-3786167-A1 | DIARYL MACROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF | Primegene (Beijing) Co., Ltd. (CN) | 2021-03-03 | — | — | EP | disclosed |
| EP-3786167-A1 | DIARYL MACROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF | Primegene (Beijing) Co., Ltd. (CN) | 2021-03-03 | — | — | EP | disclosed |