Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.67 |
| ▸ | PTGFR | P43088 | 2/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL655606 | 0.99 | PRKCZ (0.66) | PRKCZPTGFRGABBR2GABBR1LMNA | |
| SCHEMBL2303141 | 0.93 | PRKCZ (0.64) | PRKCZPTGFRGABBR2GABBR1LMNA | |
| Hydrochloric Acid SCHEMBL658550 | 0.92 | PRKCZ (0.62) | PRKCZPTGFRGABBR2GABBR1LMNA | |
| SCHEMBL2303759 | 0.91 | PRKCZ (0.77) | PRKCZPTGFRGABBR2GABBR1LMNA | |
| SCHEMBL659483 | 0.91 | PRKCZ (0.72) | PRKCZGABBR2GABBR1LMNACYP2C9 | |
| Hydrochloric Acid SCHEMBL657199 | 0.90 | PRKCZ (0.71) | PRKCZGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL657599 | 0.87 | PRKCZ (0.67) | PRKCZPTGFRGABBR2GABBR1LMNA | |
| SCHEMBL2303557 | 0.87 | PRKCZ (0.84) | PRKCZGABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL2303149 | 0.87 | PRKCZ (0.77) | PRKCZPTGFRGABBR2GABBR1LMNA | |
| SCHEMBL2302664 | 0.87 | PRKCZ (0.67) | PRKCZGABBR2GABBR1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | claimed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |