Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL657754 | 0.99 | PRKCZ (0.52) | PRKCZPIN1KDM4ECTNNB1HDAC3 | |
| SCHEMBL10286932 | 0.92 | PRKCZ (0.60) | PRKCZPIN1 | |
| SCHEMBL2301098 | 0.87 | PRKCZ (0.52) | PRKCZPIN1KDM4E | |
| Hydrochloric Acid SCHEMBL657402 | 0.86 | PRKCZ (0.51) | PRKCZPIN1KDM4E | |
| SCHEMBL2304106 | 0.86 | PRKCZ (0.63) | PRKCZKDM4E | |
| SCHEMBL10252791 | 0.85 | PRKCZ (0.62) | PRKCZPIN1KDM4EHDAC3HDAC4 | |
| SCHEMBL2305249 | 0.85 | PRKCZ (0.59) | PRKCZPIN1KDM4ETP53MAPT | |
| Hydrochloric Acid SCHEMBL657836 | 0.85 | PRKCZ (0.62) | PRKCZKDM4E | |
| SCHEMBL2303594 | 0.85 | PRKCZ (0.64) | PRKCZPIN1KDM4E | |
| SCHEMBL2301731 | 0.85 | PRKCZ (0.62) | PRKCZPIN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |