Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | S100B | P04271 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29978474 | 1.00 | KDM4E (0.70) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL29979084 | 0.84 | HTT (0.68) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL23043725 | 0.84 | HTT (0.68) | KDM4EHTTGAAMAPTTP53 | |
| Hydrochloric Acid SCHEMBL29978709 | 0.82 | HTT (1.00) | KDM4EHTTGAAMAPTTP53 | |
| Hydrochloric Acid SCHEMBL23043576 | 0.82 | HTT (1.00) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL23043687 | 0.81 | GAA (0.62) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL29979173 | 0.81 | GAA (0.62) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL19144322 | 0.81 | KDM4E (0.46) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL30667261 | 0.80 | S100B (0.61) | KDM4EHTTGAAMAPTTP53 | |
| SCHEMBL3076827 | 0.80 | GAA (0.65) | KDM4EHTTGAAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041866-A1 | SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-03-04 | — | — | WO | disclosed |