Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL14250160 | 1.00 | HDAC4 (0.38) | HDAC4HDAC2HDAC8HDAC6TAAR1 | |
| Acrylic Acid SCHEMBL29190879 | 0.92 | LMNA (0.39) | HDAC4HDAC2HDAC8HDAC6TAAR1 | |
| Benzene SCHEMBL28198980 | 0.89 | KDM1A (0.30) | — | |
| SCHEMBL27206 | 0.89 | — | — | |
| SCHEMBL8586607 | 0.89 | — | — | |
| SCHEMBL14250159 | 0.89 | HDAC4 (0.34) | HDAC4HDAC2HDAC8HDAC6TAAR1 | |
| Succinic Acid SCHEMBL3805567 | 0.89 | FFAR1 (0.40) | HDAC4HDAC2HDAC8HDAC6TAAR1 | |
| SCHEMBL868582 | 0.87 | KDM1A (0.31) | HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL117201 | 0.87 | KDM1A (0.31) | HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL10709752 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217442-A | Modified amine chain extender, polyurethane coating and preparation method thereof | 北京东方雨虹防水技术股份有限公司 | 2023-06-06 | — | — | CN | claimed |
| CN-106008900-B | A kind of polyurethane-polyesteramide compound and preparation method thereof | 河北工业大学 | 2018-11-27 | — | — | CN | claimed |
| CN-106008900-A | Polyurethane-polyesteramide compound and preparation method thereof | 河北工业大学 | 2016-10-12 | — | — | CN | claimed |
| CN-117467230-A | Composition and method of manufacture of articles | IP传输控股公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-116217442-A | Modified amine chain extender, polyurethane coating and preparation method thereof | 北京东方雨虹防水技术股份有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-112745496-B | Method for improving thermal stability of polycarbonate | 中国石油化工股份有限公司 | 2023-05-16 | — | — | CN | disclosed |
| US-11236197-B2 | Multi-block copolymers | IP2IPO INNOVATIONS LIMITED (GB) | 2022-02-01 | — | — | US | disclosed |
| CN-112745496-A | Method for improving thermal stability of polycarbonate | 中国石油化工股份有限公司 | 2021-05-04 | — | — | CN | disclosed |
| US-10293573-B2 | Micro flow channel chip and method for producing flow channel chip | SUMITOMO BAKELITE COMPANY LIMITED (JP) | 2019-05-21 | — | — | US | disclosed |
| US-20190010277-A1 | MULTI-BLOCK COPOLYMERS | IMPERIAL INNOVATIONS LIMITED (GB) | 2019-01-10 | — | — | US | disclosed |
| CN-106008900-B | A kind of polyurethane-polyesteramide compound and preparation method thereof | 河北工业大学 | 2018-11-27 | — | — | CN | disclosed |
| WO-2012092447-A1 | POLYMER COMPOSITIONS FOR TEMPORARY BONDING | PROMERUS, LLC (US) | 2012-07-05 | — | — | WO | disclosed |
| US-20120172479-A1 | POLYMER COMPOSITIONS FOR TEMPORARY BONDING | PROMERUS LLC (US) | 2012-07-05 | — | — | US | disclosed |
| US-20110318938-A1 | TEMPORARY BONDING ADHESIVE FOR A SEMICONDUCTOR WAFER AND METHOD FOR MANUFACTURING A SEMICONDUCTOR DEVICE USING THE SAME | SUMITOMO BAKELITE CO., LTD. (JP) | 2011-12-29 | — | — | US | disclosed |
| US-20110263095-A1 | TEMPORARY BONDING ADHESIVE FOR A SEMICONDUCTOR WAFER AND METHOD FOR MANUFACTURING A SEMICONDUCTOR DEVICE USING THE SAME | SUMITOMO BAKELITE CO., LTD. (JP) | 2011-10-27 | — | — | US | disclosed |
| EP-2351804-A1 | TEMPORARILY FIXING AGENT FOR SEMICONDUCTOR WAFER, AND PROCESS FOR PRODUCTION OF SEMICONDUCTOR DEVICE USING SAME | Sumitomo Bakelite Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |
| EP-2351805-A1 | TEMPORARILY FIXING AGENT FOR SEMICONDUCTOR WAFER, AND PROCESS FOR PRODUCTION OF SEMICONDUCTOR DEVICE USING SAME | Sumitomo Bakelite Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |
| EP-2264112-A2 | Temporary bonding adhesive for a semiconductor wafer and method for manufacturing a semiconductor device using the same, and use of a resin composition as a temporary bonding adhesive | Sumitomo Bakelite Co., Ltd. (JP) | 2010-12-22 | — | — | EP | disclosed |
| EP-2264113-A2 | Temporary bonding adhesive for a semiconductor wafer and method for manufacturing a semiconductor device using the same, and use of a resin composition as a temporary bonding adhesive | Sumitomo Bakelite Co., Ltd. (JP) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009025850-A2 | COPOLYMERIZATION OF EPOXIDES AND CYCLIC ANHYDRIDES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2009-02-26 | — | — | WO | disclosed |