SCHEMBL23044167

SCHEMBL23044167

CC(C)NC(=O)c1cc(-c2ccc(NC(=O)C(O)c3cc(F)cc(F)c3)cc2)cnc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EIF2AK3 Q9NZJ5 19/20 1.00
EIF2S1 P05198 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29688051 1.00 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL23044252 1.00 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL28774951 1.00 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL23059406 0.90 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL29688002 0.89 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL20541830 0.89 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL23044519 0.89 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL29687742 0.89 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL23044599 0.89 EIF2AK3 (1.00) EIF2AK3EIF2S1
SCHEMBL29831258 0.89 EIF2AK3 (1.00) EIF2AK3EIF2S1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220332722-A1 PERK INHIBITING COMPOUNDS HIBERCELL, INC. 2022-10-20 US claimed
EP-4021893-A1 PERK INHIBITING COMPOUNDS Hibercell, Inc. (US) 2022-07-06 EP claimed
CN-114585606-A PERK inhibiting compounds 希伯塞尔股份有限公司 2022-06-03 CN claimed
WO-2021231782-A1 PERK INHIBITORS FOR TREATING VIRAL INFECTIONS HIBERCELL, INC. (US) 2021-11-18 WO claimed
WO-2021041973-A1 PERK INHIBITING COMPOUNDS HIBERCELL, INC. (US) 2021-03-04 WO claimed
US-12473296-B2 Perk inhibiting compounds HIBERCELL, INC. (US) 2025-11-18 US disclosed
US-20220332722-A1 PERK INHIBITING COMPOUNDS HIBERCELL, INC. 2022-10-20 US disclosed
EP-4021893-A1 PERK INHIBITING COMPOUNDS Hibercell, Inc. (US) 2022-07-06 EP disclosed
CN-114585606-A PERK inhibiting compounds 希伯塞尔股份有限公司 2022-06-03 CN disclosed
WO-2021231782-A1 PERK INHIBITORS FOR TREATING VIRAL INFECTIONS HIBERCELL, INC. (US) 2021-11-18 WO disclosed
WO-2021041973-A1 PERK INHIBITING COMPOUNDS HIBERCELL, INC. (US) 2021-03-04 WO disclosed
WO-2021041973-A1 PERK INHIBITING COMPOUNDS HIBERCELL, INC. (US) 2021-03-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220332722-A1 PERK INHIBITING COMPOUNDS ATF4, EEF2K, ERN1 EIF2AK3 75/4885EIF2S1 380/4885
US-12473296-B2 Perk inhibiting compounds MAPK1, ERN1, MAP3K20 EIF2AK3 69/4885EIF2S1 139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.