Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.81 |
| ▸ | INSR | P06213 | 19/20 | 0.81 |
| ▸ | IGF1R | P08069 | 19/20 | 0.81 |
| ▸ | AURKA | O14965 | 2/20 | 0.81 |
| ▸ | ROS1 | P08922 | 2/20 | 0.81 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.81 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.81 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.81 |
| ▸ | JAK2 | O60674 | 1/20 | 0.81 |
| ▸ | STK10 | O94804 | 1/20 | 0.81 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.81 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.81 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.81 |
| ▸ | ABL1 | P00519 | 1/20 | 0.81 |
| ▸ | EGFR | P00533 | 1/20 | 0.81 |
| ▸ | CD74 | P04233 | 1/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.81 |
| ▸ | LCK | P06239 | 1/20 | 0.81 |
| ▸ | FYN | P06241 | 1/20 | 0.81 |
| ▸ | FES | P07332 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11916453 | 0.92 | INSR (0.85) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916541 | 0.91 | ALK (0.93) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL15217783 | 0.90 | INSR (0.84) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL30761549 | 0.90 | ALK (0.84) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL21133482 | 0.90 | ALK (0.84) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916613 | 0.90 | ALK (0.87) | ALKINSRIGF1RAURKAROS1 | |
| Brigatinib SCHEMBL29350096 | 0.89 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| Brigatinib SCHEMBL11916361 | 0.89 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| Brigatinib SCHEMBL29432539 | 0.89 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916537 | 0.89 | INSR (1.00) | ALKINSRIGF1RAURKAROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4019021-A1 | COMPOUND INHIBITING AND INDUCING DEGRADATION OF EGFR AND ALK | Beijing Tide Pharmaceutical Co., Ltd. (CN) | 2022-06-29 | — | — | EP | disclosed |
| CN-114286678-A | Compounds for inhibiting and inducing degradation of EGFR and ALK | 北京泰德制药股份有限公司 | 2022-04-05 | — | — | CN | disclosed |
| WO-2021036922-A1 | COMPOUND INHIBITING AND INDUCING DEGRADATION OF EGFR AND ALK | 北京泰德制药股份有限公司 | 2021-03-04 | — | — | WO | disclosed |
| WO-2021036922-A1 | COMPOUND INHIBITING AND INDUCING DEGRADATION OF EGFR AND ALK | 北京泰德制药股份有限公司 | 2021-03-04 | — | — | WO | disclosed |