⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19948004 | 1.00 | — | — | |
| SCHEMBL30085043 | 0.81 | MEN1 (0.49) | — | |
| SCHEMBL30111470 | 0.81 | MEN1 (0.43) | — | |
| SCHEMBL29841929 | 0.80 | — | — | |
| SCHEMBL3766415 | 0.78 | TACR1 (0.39) | — | |
| SCHEMBL20744897 | 0.78 | TACR1 (0.39) | — | |
| SCHEMBL3766440 | 0.78 | TACR1 (0.39) | — | |
| SCHEMBL14808728 | 0.78 | VNN1 (0.32) | — | |
| SCHEMBL4684468 | 0.77 | TACR1 (0.33) | — | |
| SCHEMBL5147079 | 0.77 | TACR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989321-B | KRAS G12C inhibitors | 米拉蒂治疗股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114269735-B | Dihydro-or tetrahydroquinazoline compound, intermediate thereof, preparation method and application | 南京创济生物医药有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-109843856-B | KRAS G12C inhibitors | 米拉蒂治疗股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-115803030-A | Compounds and methods for KRAS-targeted degradation | 阿维纳斯企业公司 | 2023-03-14 | — | — | CN | disclosed |
| WO-2022127827-A1 | KRASG12C PROTEIN MUTATION INHIBITOR AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 上海维申医药有限公司 | 2022-06-23 | — | — | WO | disclosed |
| CN-114269735-A | Dihydro or tetrahydro quinazoline compound and intermediate, preparation method and application thereof | 南京创济生物医药有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021037018-A1 | DIHYDROQUINAZOLINE OR TETRAHYDROQUINAZOLINE COMPOUND AND INTERMEDIATES, PREPARATION METHODS AND USE THEREOF | 南京创济生物医药有限公司 | 2021-03-04 | — | — | WO | disclosed |