Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | DRD3 | P35462 | 9/20 | 0.55 |
| ▸ | HTR2A | P28223 | 7/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15747671 | 1.00 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL2304584 | 1.00 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL978461 | 0.90 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL978459 | 0.90 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL977900 | 0.89 | DRD2 (0.60) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL977903 | 0.89 | DRD2 (0.56) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL977902 | 0.89 | DRD2 (0.56) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL977901 | 0.89 | DRD2 (0.60) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL978819 | 0.89 | DRD2 (0.51) | DRD2DRD3HTR2AHTR1ADRD1 | |
| SCHEMBL978818 | 0.89 | DRD2 (0.51) | DRD2DRD3HTR2AHTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132185-B1 | PYRIMIDINYL-PIPERAZINES USEFUL AS DOPAMINE D3/D2 RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2011-08-03 | — | — | EP | claimed |