Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 10/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | HCK | P08631 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.42 |
| ▸ | PRKDC | P78527 | 4/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683789 | 0.79 | BTK (0.41) | ATRSRCEGFRHCKABL1 | |
| SCHEMBL19683815 | 0.79 | LCK (0.64) | SRCEGFRHCKPIK3CDKDR | |
| SCHEMBL20873190 | 0.75 | FLT3 (0.66) | RETLCKCSF1RPDGFRBKIT | |
| SCHEMBL20878854 | 0.74 | SRC (0.40) | ATRSRCEGFRHCKPIK3CD | |
| SCHEMBL19683625 | 0.68 | FLT3 (0.65) | RETLCKCSF1RPDGFRBKIT | |
| SCHEMBL20873203 | 0.66 | FLT3 (0.66) | RETLCKCSF1RPDGFRBKIT | |
| SCHEMBL19683615 | 0.66 | FLT3 (0.68) | RETLCKCSF1RPDGFRBKIT | |
| SCHEMBL19683620 | 0.66 | FLT3 (0.68) | RETLCKCSF1RPDGFRBKIT | |
| SCHEMBL23047333 | 0.66 | FLT3 (0.47) | ATRSRCEGFRHCKPIK3CD | |
| SCHEMBL14574734 | 0.65 | SRC (0.60) | ATRSRCEGFRHCKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |