Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.65 |
| ▸ | LCK | P06239 | 5/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | CDK11B | P21127 | 1/20 | 0.65 |
| ▸ | CCNC | P24863 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | CDK8 | P49336 | 1/20 | 0.65 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.65 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683613 | 0.88 | BTK (0.63) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683609 | 0.84 | LCK (0.60) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683819 | 0.83 | FLT3 (0.81) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683590 | 0.83 | FLT3 (0.72) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683779 | 0.82 | FLT3 (0.77) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683815 | 0.81 | LCK (0.64) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL20873189 | 0.81 | FLT3 (0.70) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683700 | 0.81 | FLT3 (0.48) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683823 | 0.81 | FLT3 (0.73) | BTKLCKCSF1RRETPDGFRB | |
| SCHEMBL19683607 | 0.81 | RET (0.84) | BTKLCKCSF1RRETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |