Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.54 |
| ▸ | GSK3B | P49841 | 15/20 | 0.54 |
| ▸ | WNT1 | P04628 | 10/20 | 0.54 |
| ▸ | CLK2 | P49760 | 3/20 | 0.50 |
| ▸ | CLK3 | P49761 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23916290 | 0.85 | DYRK1A (0.54) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916379 | 0.76 | DYRK1A (0.52) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916770 | 0.76 | DYRK1A (0.62) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23048620 | 0.76 | DYRK1A (0.54) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916324 | 0.76 | DYRK1A (0.68) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916834 | 0.75 | DYRK1A (0.53) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916939 | 0.74 | DYRK1A (0.44) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19540396 | 0.73 | DYRK1A (0.66) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916319 | 0.71 | DYRK1A (0.82) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19540385 | 0.71 | DYRK1A (0.73) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |