Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.44 |
| ▸ | WNT1 | P04628 | 8/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | CLK3 | P49761 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 7/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23916750 | 0.81 | DYRK1A (0.44) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL23048669 | 0.79 | NNMT (0.38) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL23916185 | 0.76 | DYRK1A (0.37) | DYRK1AWNT1ABL1GSK3B | |
| SCHEMBL23916726 | 0.76 | ABL1 (0.40) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL23048824 | 0.74 | DYRK1A (0.54) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916770 | 0.74 | DYRK1A (0.62) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916379 | 0.71 | DYRK1A (0.52) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916678 | 0.69 | DYRK1A (0.59) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL23916128 | 0.65 | DYRK1A (0.41) | DYRK1AWNT1CLK2CLK3ABL1 | |
| SCHEMBL19540167 | 0.64 | DYRK1A (0.65) | DYRK1AWNT1CLK2CLK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |