Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.52 |
| ▸ | WNT1 | P04628 | 15/20 | 0.52 |
| ▸ | GSK3B | P49841 | 15/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23741456 | 0.86 | DYRK1A (0.61) | DYRK1AWNT1GSK3BABL1 | |
| SCHEMBL23048870 | 0.82 | DYRK1A (0.64) | DYRK1AWNT1GSK3BABL1 | |
| SCHEMBL23048671 | 0.82 | DYRK1A (0.57) | DYRK1AWNT1GSK3BABL1 | |
| SCHEMBL23741004 | 0.82 | GSK3B (0.52) | DYRK1AWNT1GSK3B | |
| SCHEMBL23048651 | 0.81 | DYRK1A (0.51) | DYRK1AWNT1GSK3BABL1 | |
| SCHEMBL24219313 | 0.78 | DYRK1A (0.48) | DYRK1AWNT1GSK3BABL1 | |
| SCHEMBL19516201 | 0.77 | DYRK1A (0.62) | DYRK1AWNT1GSK3B | |
| SCHEMBL23741128 | 0.76 | DYRK1A (0.47) | DYRK1AWNT1GSK3BABL1 | |
| SCHEMBL19546787 | 0.75 | GSK3B (0.57) | DYRK1AWNT1GSK3B | |
| SCHEMBL19515981 | 0.75 | DYRK1A (0.76) | DYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |