Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.64 |
| ▸ | GSK3B | P49841 | 15/20 | 0.64 |
| ▸ | WNT1 | P04628 | 14/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048671 | 0.86 | DYRK1A (0.57) | DYRK1AGSK3BWNT1ABL1CLK2 | |
| SCHEMBL23048651 | 0.84 | DYRK1A (0.51) | DYRK1AGSK3BWNT1ABL1CLK2 | |
| SCHEMBL23048869 | 0.82 | DYRK1A (0.52) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL23741128 | 0.82 | DYRK1A (0.47) | DYRK1AGSK3BWNT1ABL1CLK2 | |
| SCHEMBL24219313 | 0.81 | DYRK1A (0.48) | DYRK1AGSK3BWNT1ABL1CLK2 | |
| SCHEMBL25890706 | 0.81 | AR (0.54) | DYRK1AGSK3BWNT1KDR | |
| SCHEMBL23741456 | 0.79 | DYRK1A (0.61) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL19516218 | 0.79 | DYRK1A (1.00) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL30005459 | 0.79 | DYRK1A (1.00) | DYRK1AGSK3BWNT1ABL1 | |
| SCHEMBL19546787 | 0.78 | GSK3B (0.57) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943086-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BioSplice Therapeutics, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |