Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 17/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8485848 | 0.91 | LTB4R2 (0.41) | LTB4R2AGTR1OXTRAVPR1AFFAR1 | |
| SCHEMBL2515 | 0.90 | LTB4R2 (0.49) | LTB4R2AGTR1OXTRAVPR1AFFAR1 | |
| SCHEMBL2445 | 0.84 | LTB4R2 (0.53) | LTB4R2AGTR1OXTRAVPR1AFFAR1 | |
| SCHEMBL2730 | 0.83 | LTB4R2 (0.53) | LTB4R2AGTR1OXTRAVPR1A | |
| SCHEMBL2225 | 0.81 | LTB4R2 (0.54) | LTB4R2AGTR1OXTRAVPR1A | |
| SCHEMBL1986 | 0.81 | LTB4R2 (0.53) | LTB4R2AGTR1OXTRAVPR1A | |
| SCHEMBL1900 | 0.81 | LTB4R2 (0.53) | LTB4R2AGTR1OXTRAVPR1AFFAR1 | |
| SCHEMBL1711 | 0.80 | LTB4R2 (0.49) | LTB4R2AGTR1OXTRAVPR1AFFAR1 | |
| SCHEMBL2089 | 0.80 | LTB4R2 (0.55) | LTB4R2AGTR1 | |
| SCHEMBL9429769 | 0.80 | LTB4R2 (0.49) | LTB4R2AGTR1OXTRAVPR1AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |