⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14406111 | 0.86 | — | — | |
| SCHEMBL11595046 | 0.84 | — | — | |
| SCHEMBL11785666 | 0.84 | — | — | |
| Cyclopentane SCHEMBL9241252 | 0.81 | ALDH1A1 (0.32) | — | |
| SCHEMBL11868695 | 0.81 | TRIM24 (0.39) | — | |
| SCHEMBL1268348 | 0.81 | — | — | |
| SCHEMBL11430713 | 0.81 | TRIM24 (0.39) | — | |
| SCHEMBL1332708 | 0.73 | — | — | |
| SCHEMBL11540138 | 0.71 | — | — | |
| Formic Acid SCHEMBL28500043 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350311-B1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | MADRIGAL PHARMACEUTICALS INC (US) | 2013-12-25 | — | — | EP | claimed |
| US-8324385-B2 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. (US) | 2012-12-04 | — | — | US | claimed |
| CN-102203280-A | Diacylglycerol acyltransferase inhibitors | VIA PHARMACEUTICALS INC | 2011-09-28 | — | — | CN | claimed |
| EP-2350311-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2011-08-03 | — | — | EP | claimed |
| WO-2010056506-A1 | DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | WO | claimed |
| US-20100113782-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | claimed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | claimed |
| CN-118892824-A | Catalyst for preparing cyclopropane ketone, preparation method thereof and preparation method of cyclopropane ketone | 北京航天试验技术研究所 | 2024-11-05 | — | — | CN | disclosed |
| CN-116854650-A | 2, 3-dihydrofuran derivative and synthetic method and application thereof | 江西省科学院应用化学研究所 | 2023-10-10 | — | — | CN | disclosed |
| CN-109678688-B | Novel preparation method of cyclopropane ketone | 瑞孚信江苏药业股份有限公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-110240563-A | A kind of rich preparation method for Buddhist nun of card | 南京法恩化学有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-107266497-A | A kind of purposes of phosphoryl carboxylic acid derivative its preparation method and Pharmaceutical composition | 陕西合成药业股份有限公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-107266365-A | A kind of purposes of prasugrel analog derivative its preparation method and Pharmaceutical composition | 陕西合成药业股份有限公司 | 2017-10-20 | — | — | CN | disclosed |
| US-5856503-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| CN-1040540-C | Thioether conjugates of anthracycline antibiotics, process for their preparation and pharmaceutical compositions containing them | BRISTOL MYERS SQUIBB CO (US) | 1998-11-04 | — | — | CN | disclosed |
| CN-1180711-A | Thioether conjugates | BRISTOL MYERS SQUIBB CO (US) | 1998-05-06 | — | — | CN | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |
| CN-1074684-A | Thioether conjugates | BRISTOL MYERS SQUIBB CO (US) | 1993-07-28 | — | — | CN | disclosed |
| US-3932318-A | COPOLYMERS WITH ISOCYANATES, CRYOGENIC POLYMERIZATION, NONFLAMMABLE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-01-13 | — | — | US | disclosed |