Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 3/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655409 | 0.79 | DYRK1A (0.50) | DYRK1AKEAP1SYKMEN1CYP1A2 | |
| SCHEMBL20814475 | 0.78 | POLB (0.50) | SYKTDP1 | |
| SCHEMBL23055242 | 0.77 | PIK3CD (0.38) | DYRK1ASYKKMT2ANAMPTTDP1 | |
| SCHEMBL13994051 | 0.75 | DYRK1A (0.46) | DYRK1AKEAP1SYKMEN1CYP1A2 | |
| SCHEMBL13996528 | 0.75 | KEAP1 (0.50) | DYRK1AKEAP1SYKMEN1CYP1A2 | |
| SCHEMBL61665 | 0.74 | DYRK1A (0.49) | DYRK1AKEAP1SYKMEN1CYP1A2 | |
| SCHEMBL21646356 | 0.74 | DYRK1A (0.47) | DYRK1ASYKCYP1A2NAMPTTDP1 | |
| SCHEMBL19764528 | 0.73 | KEAP1 (0.57) | DYRK1AKEAP1NAMPT | |
| SCHEMBL24032041 | 0.72 | DYRK1A (0.44) | DYRK1AKEAP1SYKMEN1CYP1A2 | |
| SCHEMBL20991102 | 0.72 | DYRK1A (0.44) | DYRK1AKEAP1SYKMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4104861-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-21 | — | — | EP | disclosed |
| WO-2021149767-A1 | HETEROCYCLIC DERIVATIVE | 大日本住友製薬株式会社 | 2021-07-29 | — | — | WO | disclosed |
| EP-3828174-A1 | PYRIDAZINONE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2021-06-02 | — | — | EP | disclosed |
| WO-2021039961-A1 | RING-FUSED PYRAZOLE DERIVATIVE | 大日本住友製薬株式会社 | 2021-03-04 | — | — | WO | disclosed |