Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 6/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609414 | 0.86 | NOTUM (0.33) | EGFRSRCABL1KDM4EKDR | |
| SCHEMBL10260251 | 0.80 | PIK3CD (0.52) | EGFRSRCABL1KDRMTOR | |
| SCHEMBL22748995 | 0.78 | DYRK3 (0.51) | EGFRSRCKDRLIMK1RET | |
| SCHEMBL23057505 | 0.78 | EGFR (0.41) | EGFRSRCABL1KDM4EKDR | |
| SCHEMBL13019650 | 0.76 | SRC (0.64) | EGFRSRCABL1KDM4EKDR | |
| SCHEMBL10261498 | 0.76 | PIK3CD (0.53) | EGFRSRCABL1KDM4EKDR | |
| SCHEMBL10261918 | 0.76 | SRC (0.66) | EGFRSRCABL1KDRMTOR | |
| SCHEMBL18599138 | 0.74 | EGFR (0.39) | EGFRSRCABL1KDM4EKDR | |
| SCHEMBL24096479 | 0.73 | SRC (0.61) | EGFRSRCABL1KDRMTOR | |
| SCHEMBL10261070 | 0.72 | SRC (0.52) | EGFRSRCABL1KDM4EKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021038540-A1 | CYCLOALKYLIDENE CARBOXYLIC ACIDS AND DERIVATIVES AS BTK INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-03-04 | — | — | WO | disclosed |