Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.55 |
| ▸ | JAK3 | P52333 | 16/20 | 0.55 |
| ▸ | JAK2 | O60674 | 13/20 | 0.55 |
| ▸ | TYK2 | P29597 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26962966 | 0.83 | JAK1 (0.58) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL29892586 | 0.83 | JAK1 (0.58) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL21383203 | 0.76 | JAK1 (0.74) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL20183339 | 0.74 | JAK2 (0.89) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL21383383 | 0.74 | JAK1 (0.70) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL21400281 | 0.73 | JAK2 (0.77) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL21400462 | 0.73 | JAK2 (0.65) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL3534102 | 0.73 | JAK3 (0.97) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL21385108 | 0.72 | JAK1 (0.56) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL29892600 | 0.72 | JAK1 (0.61) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021041392-A1 | SUBSTITUTED (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO COMPOUNDS USEFUL AS JAK1 INHIBITORS | CHEMWERTH, INC. (US) | 2021-03-04 | — | — | WO | disclosed |