Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.61 |
| ▸ | JAK3 | P52333 | 15/20 | 0.61 |
| ▸ | JAK2 | O60674 | 14/20 | 0.60 |
| ▸ | TYK2 | P29597 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26962813 | 1.00 | JAK1 (0.61) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962903 | 0.92 | JAK1 (0.59) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL27133804 | 0.92 | JAK1 (0.59) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29892586 | 0.89 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962966 | 0.89 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962782 | 0.88 | JAK1 (0.65) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL27131196 | 0.88 | JAK1 (0.65) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26962975 | 0.88 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL29892665 | 0.88 | JAK1 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26963025 | 0.85 | JAK1 (0.64) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492204-B2 | Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl) amino compounds useful as JAK 1 inhibitors | CHEMWERTH, INC. (US) | 2025-12-09 | — | — | US | disclosed |
| EP-4021452-B1 | SUBSTITUTED (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO COMPOUNDS USEFUL AS JAK1 INHIBITORS | CHEMWERTH INC (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20220274992-A1 | SUBSTITUTED (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL) AMINO COMPOUNDS USEFUL AS JAK 1 INHIBITORS | CHEMWERTH, INC. | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220274992-A1 | SUBSTITUTED (7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL) AMINO COMPOUNDS USEFUL AS JAK 1 INHIBITORS | JAK1, JAK3, JAK2 | JAK1 1/4885JAK3 2/4885JAK2 3/4885 |
| US-12492204-B2 | Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl) amino compounds useful as JAK 1 inhibitors | JAK1, JAK3, JAK2 | JAK1 1/4885JAK3 2/4885JAK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.