Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 13/20 | 0.45 |
| ▸ | PDE9A | O76083 | 7/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30748216 | 0.85 | PDE9A (0.41) | PDE8BPDE9APDE1C | |
| SCHEMBL29174835 | 0.85 | PDE9A (0.41) | PDE8BPDE9APDE1C | |
| SCHEMBL30748221 | 0.85 | PDE9A (0.41) | PDE8BPDE9APDE1C | |
| SCHEMBL30748213 | 0.84 | PDE9A (0.37) | PDE8BPDE9APDE1C | |
| SCHEMBL29174802 | 0.84 | PDE9A (0.37) | PDE8BPDE9APDE1C | |
| SCHEMBL179563 | 0.77 | PDE8B (0.40) | PDE8B | |
| SCHEMBL23059281 | 0.77 | PDE8B (0.40) | PDE8B | |
| SCHEMBL23059284 | 0.77 | PDE8B (0.41) | PDE8B | |
| SCHEMBL23059289 | 0.74 | PDE9A (0.37) | PDE9A | |
| SCHEMBL29174800 | 0.71 | PDE9A (0.39) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210060022-A1 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS | INFINITY PHARMACEUTICALS, INC. | 2021-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210060022-A1 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS | PIK3CA, MCL1, PIK3CB | PDE8B 1354/4885PDE9A 1082/4885PDE1C 913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.