Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.45 |
| ▸ | SCD | O00767 | 3/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12650282 | 0.86 | CCNC (0.43) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNA7 | |
| SCHEMBL10002512 | 0.82 | RIPK1 (0.64) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL19217206 | 0.81 | RIPK1 (0.62) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL8275419 | 0.81 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL17454944 | 0.81 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL22322395 | 0.80 | DPP4 (0.40) | RIPK1 | |
| SCHEMBL6960066 | 0.80 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL18642714 | 0.80 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL23064515 | 0.79 | RIPK1 (0.59) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 | |
| SCHEMBL20178113 | 0.79 | RIPK1 (0.59) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024140678-A1 | A KETAL PROTECTED INTERMEDIATE FOR SONROTOCLAX AND PREPARATION METHOD THEREOF | BEIGENE (SUZHOU) CO., LTD. (CN) | 2024-07-04 | — | — | WO | disclosed |
| WO-2024017354-A1 | METHODS OF TREATING MULTIPLE MYELOMA USING BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2024-01-25 | — | — | WO | disclosed |
| WO-2021110102-A1 | METHODS OF CANCER TREATMENT USING BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021083135-A1 | Bcl-2 INHIBITORS | BEIGENE, LTD. (KY) | 2021-05-06 | — | — | WO | disclosed |
| EP-3788042-A1 | BCL-2 INHIBITORS | BeiGene, Ltd. (KY) | 2021-03-10 | — | — | EP | disclosed |