Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27891098 | 0.92 | TAAR1 (0.57) | TAAR1CNR1SLC6A4SLC6A3DRD2 | |
| SCHEMBL9799321 | 0.81 | TAAR1 (0.63) | TAAR1SLC6A4SLC6A3DRD2MAOB | |
| SCHEMBL6338302 | 0.81 | SNCA (0.47) | TAAR1CNR1PPARGPPARALMNA | |
| SCHEMBL2303570 | 0.80 | DRD2 (0.54) | TAAR1CNR1SLC6A4SLC6A3DRD2 | |
| SCHEMBL5158636 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A4SLC6A3DRD2MAOB | |
| SCHEMBL29813717 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A4SLC6A3DRD2MAOB | |
| SCHEMBL9799248 | 0.78 | CYP19A1 (0.63) | TAAR1IGF1RALOX15GPR84HTR2B | |
| SCHEMBL10812127 | 0.78 | HTR2A (0.60) | TAAR1CNR1IGF1RALOX15GPR84 | |
| SCHEMBL3371633 | 0.77 | TAAR1 (0.74) | TAAR1SLC6A4SLC6A3DRD2 | |
| SCHEMBL18050371 | 0.77 | TAAR1 (0.62) | TAAR1IGF1RALOX15GPR84MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |