Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 4/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.46 |
| ▸ | ITGAL | P20701 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309016 | 0.93 | ITGB2 (0.46) | ITGB2ICAM1ITGALADAM17PPARG | |
| SCHEMBL2309696 | 0.89 | ITGB2 (0.44) | ITGB2ICAM1ITGALTSHRADAM17 | |
| SCHEMBL2312170 | 0.85 | ITGB2 (0.47) | ITGB2ICAM1ITGALTSHRADAM17 | |
| SCHEMBL2311993 | 0.78 | ITGB2 (0.47) | ITGB2ICAM1ITGALADAM17PPARG | |
| SCHEMBL2306893 | 0.77 | ITGB2 (0.54) | ITGB2ICAM1ITGALPPARG | |
| SCHEMBL28163340 | 0.75 | TSHR (0.60) | ITGB2ICAM1ITGALTSHRADAM17 | |
| SCHEMBL30138755 | 0.74 | TSHR (0.59) | ITGB2ICAM1ITGALTSHRADAM17 | |
| SCHEMBL5056897 | 0.74 | TSHR (0.59) | ITGB2ICAM1ITGALTSHRADAM17 | |
| SCHEMBL2310201 | 0.74 | ITGB2 (0.44) | ITGB2ICAM1ITGALADAM17HTR2A | |
| SCHEMBL2313903 | 0.73 | NHERF1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350014-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2011-08-03 | — | — | EP | claimed |
| EP-2350014-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2011-08-03 | — | — | EP | disclosed |