Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 20/20 | 0.67 |
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.67 |
| ▸ | TLR9 | Q9NR96 | 19/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29844897 | 1.00 | TLR8 (0.67) | TLR8TLR7TLR9 | |
| SCHEMBL23066392 | 1.00 | TLR8 (0.67) | TLR8TLR7TLR9 | |
| SCHEMBL21063048 | 0.95 | TLR8 (0.71) | TLR8TLR7TLR9 | |
| SCHEMBL29844902 | 0.95 | TLR8 (0.71) | TLR8TLR7TLR9 | |
| SCHEMBL23066330 | 0.86 | TLR8 (0.70) | TLR8TLR7TLR9 | |
| SCHEMBL29844808 | 0.86 | TLR8 (0.70) | TLR8TLR7TLR9 | |
| SCHEMBL21062564 | 0.85 | TLR9 (0.72) | TLR8TLR7TLR9 | |
| SCHEMBL21062188 | 0.85 | TLR9 (0.66) | TLR8TLR7TLR9 | |
| SCHEMBL21062186 | 0.85 | TLR9 (0.66) | TLR8TLR7TLR9 | |
| SCHEMBL29844925 | 0.85 | TLR9 (0.66) | TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030878-B2 | Substituted indole ether compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-07-09 | — | — | US | claimed |
| CN-111527080-B | Substituted indole ether compounds | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | claimed |
| EP-3724183-B1 | SUBSTITUTED INDOLE ETHER COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-08-17 | — | — | EP | claimed |
| US-20210070751-A1 | SUBSTITUTED INDOLE ETHER COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-03-11 | — | — | US | claimed |
| CN-111527080-A | Substituted indole ether compounds | 百时美施贵宝公司 | 2020-08-11 | — | — | CN | claimed |
| US-12030878-B2 | Substituted indole ether compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-07-09 | — | — | US | disclosed |
| CN-111527080-B | Substituted indole ether compounds | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-3724183-B1 | SUBSTITUTED INDOLE ETHER COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-08-17 | — | — | EP | disclosed |
| US-20210070751-A1 | SUBSTITUTED INDOLE ETHER COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-03-11 | — | — | US | disclosed |
| CN-111527080-A | Substituted indole ether compounds | 百时美施贵宝公司 | 2020-08-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070751-A1 | SUBSTITUTED INDOLE ETHER COMPOUNDS | TLR7, TLR8, TLR1 | TLR8 2/4885TLR7 1/4885TLR9 4/4885 |
| US-12030878-B2 | Substituted indole ether compounds | TLR7, TLR8, TLR1 | TLR8 2/4885TLR7 1/4885TLR9 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.