Sugi Predict

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SCHEMBL23068641

SCHEMBL23068641

CSc1nccc(-c2sc(NC(=O)Nc3ccc(CN4CCN(S(C)(=O)=O)CC4)c(C(F)(F)F)c3)nc2C)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 7/20 0.46
▸ NTRK1 P04629 2/20 0.46
▸ TEK Q02763 2/20 0.46
▸ NTRK2 Q16620 2/20 0.46
▸ RET P07949 4/20 0.46
▸ CDK8 P49336 6/20 0.45
▸ CDK2 P24941 2/20 0.45
▸ CDK1 P06493 1/20 0.45
▸ SRC P12931 7/20 0.44
▸ PIK3CA P42336 1/20 0.43
▸ KDR P35968 3/20 0.42
▸ STAT3 P40763 1/20 0.41
▸ CCNC P24863 3/20 0.40
▸ FGFR4 P22455 2/20 0.40
▸ STK25 O00506 1/20 0.40
▸ CIT O14578 1/20 0.40
▸ MAP2K7 O14733 1/20 0.40
▸ IKBKB O14920 1/20 0.40
▸ AURKA O14965 1/20 0.40
▸ GAK O14976 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29629194 1.00 ABL1 (0.46) ABL1NTRK1TEKNTRK2RET
SCHEMBL23068668 0.92 CDK8 (0.54) ABL1NTRK1TEKNTRK2RET
SCHEMBL29629216 0.92 CDK8 (0.54) ABL1NTRK1TEKNTRK2RET
SCHEMBL22684885 0.90 ABL1 (0.47) ABL1NTRK1TEKNTRK2RET
SCHEMBL29629206 0.90 ABL1 (0.47) ABL1NTRK1TEKNTRK2RET
SCHEMBL23068634 0.90 CDK8 (0.50) ABL1NTRK1TEKNTRK2RET
SCHEMBL29629262 0.90 CDK8 (0.50) ABL1NTRK1TEKNTRK2RET
SCHEMBL23068658 0.89 CDK8 (0.49) ABL1NTRK1TEKNTRK2RET
SCHEMBL29629204 0.89 CDK8 (0.49) ABL1NTRK1TEKNTRK2RET
SCHEMBL22684858 0.89 ABL1 (0.46) ABL1NTRK1TEKNTRK2RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111757881-B 5- (Pyrimidin-4-yl) thiazol-2-yl urea derivatives as therapeutic agents 澳升医药公司 2024-05-07 — — CN disclosed
US-20230092876-A1 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS AUCENTRA THERAPEUTICS PTY LTD (AU) 2023-03-23 — — US disclosed
US-11325900-B2 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents AUCENTRA HOLDINGS PTY LTD (AU) 2022-05-10 — — US disclosed
US-11325900-B2 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents AUCENTRA HOLDINGS PTY LTD (AU) 2022-05-10 — — US disclosed
US-20210070746-A1 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS AUCENTRA THERAPEUTICS PTY LTD (AU) 2021-03-11 — — US disclosed
US-20210070746-A1 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS AUCENTRA THERAPEUTICS PTY LTD (AU) 2021-03-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230092876-A1 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS CDK8, CDK18, CDK9 ABL1 268/4885NTRK1 2045/4885TEK 2224/4885
US-11325900-B2 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents CDK8, CDK18, CDK9 ABL1 268/4885NTRK1 2045/4885TEK 2224/4885
US-20210070746-A1 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS CDK8, CDK18, CDK9 ABL1 268/4885NTRK1 2045/4885TEK 2224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.