Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 1.00 |
| ▸ | NTRK3 | Q16288 | 2/20 | 1.00 |
| ▸ | JAK2 | O60674 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148409 | 0.88 | NTRK1 (0.78) | NTRK1NTRK3JAK2 | |
| SCHEMBL23948333 | 0.88 | NTRK1 (0.78) | NTRK1NTRK3JAK2 | |
| SCHEMBL23948284 | 0.88 | NTRK1 (0.78) | NTRK1NTRK3JAK2 | |
| SCHEMBL23083885 | 0.86 | NTRK1 (0.80) | NTRK1NTRK3JAK2 | |
| SCHEMBL23083868 | 0.85 | NTRK1 (0.74) | NTRK1NTRK3JAK2 | |
| SCHEMBL17821052 | 0.84 | NTRK1 (0.79) | NTRK1NTRK3JAK2 | |
| SCHEMBL20119386 | 0.84 | NTRK1 (0.72) | NTRK1NTRK3JAK2 | |
| SCHEMBL21313078 | 0.84 | NTRK1 (0.72) | NTRK1NTRK3JAK2 | |
| SCHEMBL23408760 | 0.83 | NTRK1 (0.74) | NTRK1NTRK3JAK2 | |
| SCHEMBL20015988 | 0.83 | NTRK1 (0.74) | NTRK1NTRK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |