Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.44 |
| ▸ | AXL | P30530 | 7/20 | 0.44 |
| ▸ | CMA1 | P23946 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19567654 | 0.85 | NOTUM (0.47) | METAXLTP53LMNAKDM4E | |
| SCHEMBL14969331 | 0.85 | KMT2A (0.44) | METMAPTKDM4EMERTKGSK3A | |
| SCHEMBL31091473 | 0.84 | MAPT (0.47) | METAXLTP53MAPTLMNA | |
| SCHEMBL14967303 | 0.84 | NOTUM (0.47) | METAXLMERTK | |
| SCHEMBL21785475 | 0.84 | NOTUM (0.47) | METAXLTP53MAPTLMNA | |
| SCHEMBL23071267 | 0.81 | AXL (0.41) | METAXLMERTK | |
| SCHEMBL31091421 | 0.79 | KDM4E (0.52) | METAXLCMA1TP53MAPT | |
| SCHEMBL21786021 | 0.78 | ALDH1A1 (0.45) | METAXLMERTK | |
| SCHEMBL29736937 | 0.78 | ALDH1A1 (0.45) | METAXLMERTK | |
| SCHEMBL23898342 | 0.76 | AXL (0.38) | METAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118598875-A | Pyrimidine diketone amide compound and preparation method and application thereof | 广州医科大学 | 2024-09-06 | — | — | CN | claimed |
| CN-118598875-A | Pyrimidine diketone amide compound and preparation method and application thereof | 广州医科大学 | 2024-09-06 | — | — | CN | disclosed |
| CN-116283916-B | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2024-06-11 | — | — | CN | disclosed |
| CN-116283916-A | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-112457295-B | Compound with Axl and c-Met kinase inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2022-07-26 | — | — | CN | disclosed |
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |
| CN-112457295-A | Compound with Axl and c-Met kinase inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-03-09 | — | — | CN | disclosed |