Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 9/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 9/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.45 |
| ▸ | SELL | P14151 | 2/20 | 0.42 |
| ▸ | SELP | P16109 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23078866 | 0.91 | FFAR1 (0.47) | PDCD1CD274PTGER1PTGER4PTGER3 | |
| SCHEMBL23078648 | 0.90 | CD274 (0.44) | PDCD1CD274PTGER1PTGER4PTGER3 | |
| SCHEMBL23078706 | 0.88 | CD274 (0.52) | PDCD1CD274MCL1 | |
| SCHEMBL23078645 | 0.87 | CD274 (0.44) | PDCD1CD274PTGER1PTGER4PTGER3 | |
| SCHEMBL23078705 | 0.84 | PDCD1 (0.47) | PDCD1CD274PTGER1PTGER4PTGER3 | |
| SCHEMBL23078496 | 0.84 | CD274 (0.48) | PDCD1CD274PTGER1PTGER4PTGER3 | |
| SCHEMBL23078865 | 0.83 | CD274 (0.44) | PDCD1CD274PTGER1PTGER4PTGER3 | |
| SCHEMBL23078779 | 0.82 | PDCD1 (0.51) | PDCD1CD274 | |
| SCHEMBL23078247 | 0.81 | CD274 (0.47) | PDCD1CD274MCL1 | |
| SCHEMBL23078503 | 0.80 | PDCD1 (0.52) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021043116-A1 | BIPHENYL COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国药科大学 | 2021-03-11 | — | — | WO | disclosed |