Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12174856 | 0.98 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2579232 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2579749 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2582656 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2582653 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2583719 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2590304 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2581371 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL2581375 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL19292912 | 0.70 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9ANPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021043190-A1 | ISOXAZOLO[5,4-H]QUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS | 成都赛诺希亚生物科技有限公司 | 2021-03-11 | — | — | WO | disclosed |