Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747948 | 0.84 | KMT2A (0.51) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL1748271 | 0.76 | NPC1 (0.55) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL5068457 | 0.76 | KMT2A (0.52) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL1747972 | 0.76 | KMT2A (0.52) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL6031378 | 0.73 | NPC1 (0.58) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL1748086 | 0.73 | NPC1 (0.58) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL5068844 | 0.72 | NPC1 (0.60) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL4226578 | 0.72 | NPC1 (0.60) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL4229648 | 0.72 | LMNA (0.54) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL5068496 | 0.72 | KMT2A (0.57) | NPC1KMT2AMEN1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |