Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE8A | O60658 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | PDE9A | O76083 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.54 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23082923 | 0.92 | PDE4A (0.64) | PDE4APDE1BPDE2APDE8APDE5A | |
| SCHEMBL23082961 | 0.78 | PDE4A (0.57) | PDE4APDE1BPDE1A | |
| SCHEMBL8060473 | 0.78 | PDE4A (0.88) | PDE4APDE1BPDE2APDE8APDE5A | |
| SCHEMBL23082925 | 0.78 | PDE4A (0.88) | PDE4APDE1BPDE2APDE8APDE5A | |
| SCHEMBL18844293 | 0.75 | PDE4A (0.64) | PDE4APDE1BPDE2APDE8APDE5A | |
| SCHEMBL23082964 | 0.73 | PDE4A (0.47) | PDE4APDE1BPDE1A | |
| SCHEMBL20341393 | 0.71 | PDE4A (0.97) | PDE4APDE1BPDE2APDE8APDE5A | |
| Lenrispodun SCHEMBL16324627 | 0.71 | PDE4A (1.00) | PDE4APDE1BPDE2APDE8APDE5A | |
| Lenrispodun SCHEMBL18211963 | 0.71 | PDE4A (1.00) | PDE4APDE1BPDE2APDE8APDE5A | |
| Lenrispodun SCHEMBL18771113 | 0.71 | PDE4A (1.00) | PDE4APDE1BPDE2APDE8APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046179-A1 | NOVEL COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2021-03-11 | — | — | WO | disclosed |