Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 12/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305479 | 1.00 | NR1H4 (0.45) | NR1H4GCKHCAR3HDAC3HDAC2 | |
| SCHEMBL2309348 | 0.94 | GCK (0.45) | NR1H4GCKHCAR3HDAC3HDAC2 | |
| SCHEMBL2306822 | 0.88 | NR1H4 (0.41) | NR1H4KDM4E | |
| SCHEMBL2307306 | 0.88 | NR1H4 (0.41) | NR1H4KDM4E | |
| SCHEMBL2304285 | 0.87 | NR1H4 (0.49) | NR1H4RARBRARG | |
| SCHEMBL2305514 | 0.87 | NR1H4 (0.49) | NR1H4RARBRARG | |
| SCHEMBL2306973 | 0.85 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL2307699 | 0.85 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL2305357 | 0.85 | NR1H4 (0.46) | NR1H4HDAC1 | |
| SCHEMBL2305591 | 0.85 | NR1H4 (0.46) | NR1H4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350022-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-08-03 | — | — | EP | claimed |
| WO-2010043513-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-22 | — | — | WO | claimed |
| EP-2350022-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043513-A1 | NEW BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-22 | — | — | WO | disclosed |