Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23081610 | 0.91 | RIPK1 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL23085467 | 0.89 | MAP3K14 (0.45) | RIPK1MAP3K14 | |
| SCHEMBL22590505 | 0.87 | MAP3K14 (0.57) | RIPK1MAP3K14 | |
| SCHEMBL23081626 | 0.87 | MAP3K14 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL23085717 | 0.83 | RIPK1 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL22878852 | 0.82 | RIPK1 (0.47) | RIPK1MAP3K14 | |
| SCHEMBL23085466 | 0.82 | RIPK1 (0.41) | RIPK1MAP3K14 | |
| SCHEMBL23900349 | 0.78 | RIPK1 (0.48) | RIPK1MAP3K14 | |
| SCHEMBL23085715 | 0.78 | RIPK1 (0.45) | RIPK1MAP3K14 | |
| SCHEMBL23081922 | 0.78 | MAP3K14 (0.49) | RIPK1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021203011-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-10-07 | — | — | WO | disclosed |
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |