Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 13/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23085582 | 0.89 | RIPK1 (0.39) | RIPK1MAP3K14GRM5 | |
| SCHEMBL23075914 | 0.89 | RIPK1 (0.50) | RIPK1MAP3K14 | |
| SCHEMBL23085583 | 0.88 | RIPK1 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL23085565 | 0.87 | RIPK1 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL23085614 | 0.87 | RIPK1 (0.47) | RIPK1MAP3K14GRM5 | |
| SCHEMBL23085756 | 0.86 | RIPK1 (0.47) | RIPK1MAP3K14 | |
| SCHEMBL23085485 | 0.81 | RIPK1 (0.46) | RIPK1MAP3K14 | |
| SCHEMBL23085619 | 0.81 | MAP3K14 (0.47) | RIPK1MAP3K14 | |
| SCHEMBL23081597 | 0.81 | NPC1 (0.47) | RIPK1MAP3K14 | |
| SCHEMBL23085476 | 0.81 | MAP3K14 (0.47) | RIPK1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |