Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2311438 | 0.89 | DGAT1 (0.45) | DGAT1CSF1RGAAABL1RAB9A | |
| Bicarbonate SCHEMBL2314526 | 0.88 | DGAT1 (0.67) | DGAT1CSF1RGAARORCDHODH | |
| SCHEMBL12428715 | 0.87 | DGAT1 (0.44) | DGAT1CSF1RGAAABL1NPC1 | |
| SCHEMBL2308908 | 0.87 | DGAT1 (0.76) | DGAT1HTT | |
| Bicarbonate SCHEMBL2311924 | 0.86 | DGAT1 (0.53) | DGAT1CSF1RABL1NPC1RAB9A | |
| Bicarbonate SCHEMBL2308867 | 0.86 | DGAT1 (0.59) | DGAT1GAANPC1RAB9AALDH1A1 | |
| Bicarbonate SCHEMBL2311510 | 0.86 | DGAT1 (0.77) | DGAT1GAAABL1NPC1RAB9A | |
| Bicarbonate SCHEMBL2306532 | 0.85 | DGAT1 (0.44) | DGAT1CSF1RGAANPC1RAB9A | |
| Bicarbonate SCHEMBL2309476 | 0.85 | DGAT1 (0.63) | DGAT1CSF1RGAARORCDHODH | |
| Bicarbonate SCHEMBL2309088 | 0.83 | DGAT1 (0.66) | DGAT1ABL1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |