Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 11/20 | 0.65 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.64 |
| ▸ | RAF1 | P04049 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.64 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.64 |
| ▸ | NEK2 | P51955 | 2/20 | 0.64 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.64 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.64 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.64 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.64 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.64 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | KRAS | P01116 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21222990 | 0.93 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL21223046 | 0.93 | MAP2K4 (0.65) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL23089095 | 0.91 | MAP2K4 (0.65) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL21223018 | 0.91 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL23098899 | 0.91 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL30694407 | 0.91 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL30636752 | 0.91 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL23098883 | 0.90 | MAP2K4 (0.66) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL21222913 | 0.90 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL30694406 | 0.90 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746437-B1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2024-08-21 | — | — | EP | claimed |
| CN-111788195-A | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2020-10-16 | — | — | CN | claimed |
| US-12264158-B2 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2025-04-01 | — | — | US | disclosed |
| EP-3746437-B1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2024-08-21 | — | — | EP | disclosed |
| US-20240116931-A1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2024-04-11 | — | — | US | disclosed |
| US-11858927-B2 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-11858927-B2 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-11858927-B2 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | HEPAREGENIX GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-20210078995-A1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2021-03-18 | — | — | US | disclosed |
| US-20210078995-A1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2021-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078995-A1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | MAPK4, MAP3K4, MAP4K1 | MAP2K4 30/4885BRAF 82/4885RIPK2 94/4885 |
| US-20240116931-A1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | MAPK4, MAP3K4, MAP4K1 | MAP2K4 30/4885BRAF 82/4885RIPK2 94/4885 |
| US-11858927-B2 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | MAPK4, MAP3K4, MAP4K1 | MAP2K4 30/4885BRAF 82/4885RIPK2 94/4885 |
| US-12264158-B2 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | MAPK4, MAP3K4, MAP4K1 | MAP2K4 30/4885BRAF 82/4885RIPK2 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.