Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.69 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 2/20 | 0.47 |
| ▸ | KLK1 | P06870 | 2/20 | 0.47 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23090370 | 0.85 | DHODH (0.72) | DHODHTRPV1PLGKLK1KLK6 | |
| SCHEMBL23105165 | 0.85 | DHODH (0.72) | DHODHTRPV1NR1H4LMNAMAPT | |
| SCHEMBL23090405 | 0.83 | DHODH (0.77) | DHODHTRPV1PLGKLK1KLK6 | |
| SCHEMBL23090382 | 0.81 | DHODH (1.00) | DHODHTRPV1NR1H4LMNAMAPT | |
| SCHEMBL23105331 | 0.79 | DHODH (0.72) | DHODHTRPV1PLGKLK1KLK6 | |
| SCHEMBL23090417 | 0.78 | DHODH (0.62) | DHODHTRPV1NR1H4LMNAMAPT | |
| SCHEMBL23090389 | 0.78 | DHODH (0.76) | DHODHTRPV1PLGKLK1KLK6 | |
| SCHEMBL21468516 | 0.76 | NPC1 (0.68) | DHODHTRPV1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL23090367 | 0.76 | DHODH (1.00) | DHODHNR1H4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL23090408 | 0.75 | DHODH (0.67) | DHODHTRPV1NR1H4LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066357-B2 | Benzoannulene derivatives as antiviral agents | SOUTHERN RESEARCH INSTITUTE (US) | 2021-07-20 | — | — | US | disclosed |
| US-11066357-B2 | Benzoannulene derivatives as antiviral agents | SOUTHERN RESEARCH INSTITUTE (US) | 2021-07-20 | — | — | US | disclosed |
| US-20210078937-A1 | BENZOANNULENE DERIVATIVES AS ANTIVIRAL AGENTS | SOUTHERN RESEARCH INSTITUTE | 2021-03-18 | — | — | US | disclosed |
| US-20210078937-A1 | BENZOANNULENE DERIVATIVES AS ANTIVIRAL AGENTS | SOUTHERN RESEARCH INSTITUTE | 2021-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078937-A1 | BENZOANNULENE DERIVATIVES AS ANTIVIRAL AGENTS | ZC3HAV1, MAVS, ZC3HAV1L | DHODH 344/4885TRPV1 2296/4885PLG 4498/4885 |
| US-11066357-B2 | Benzoannulene derivatives as antiviral agents | ZC3HAV1, MAVS, ZC3HAV1L | DHODH 344/4885TRPV1 2296/4885PLG 4498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.