Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.69 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.69 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.69 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23092305 | 0.97 | KRAS (0.67) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL30167488 | 0.90 | KRAS (0.63) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23092291 | 0.89 | KRAS (0.69) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105132 | 0.88 | KRAS (0.70) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL30167396 | 0.88 | KRAS (0.62) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23092312 | 0.87 | KRAS (0.69) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105193 | 0.87 | KRAS (0.64) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23105141 | 0.85 | KRAS (0.69) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL16636979 | 0.85 | KRAS (0.78) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL31657929 | 0.85 | KRAS (0.72) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021051034-A1 | RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2021-03-18 | — | — | WO | disclosed |