Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16126840 | 0.72 | NAMPT (0.42) | NAMPTDPP8DPP9DPP7CARM1 | |
| SCHEMBL17560188 | 0.70 | NAMPT (0.58) | NAMPTDPP8DPP9DPP7ABHD6 | |
| SCHEMBL1686844 | 0.70 | DPP8 (0.47) | DPP8DPP9DPP7CARM1ABHD6 | |
| Hydrochloric Acid SCHEMBL1687068 | 0.68 | DPP8 (0.46) | DPP8DPP9DPP7CARM1ABHD6 | |
| SCHEMBL16126529 | 0.67 | DPP8 (0.44) | DPP8DPP9DPP7CARM1ABHD6 | |
| SCHEMBL20237351 | 0.67 | DPP8 (0.44) | DPP8DPP9DPP7CARM1ABHD6 | |
| SCHEMBL16126534 | 0.67 | DPP8 (0.44) | DPP8DPP9DPP7CARM1ABHD6 | |
| SCHEMBL16126841 | 0.67 | NAMPT (0.49) | NAMPTCARM1DRD2DRD3OPRM1 | |
| SCHEMBL29319320 | 0.67 | ABHD6 (0.44) | NAMPTDPP8DPP9DPP7CARM1 | |
| SCHEMBL12498872 | 0.66 | DPP4 (0.44) | NAMPTDPP8DPP9DPP7ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189048-B1 | AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-03-17 | — | — | EP | disclosed |