Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14182577 | 0.78 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL1739227 | 0.75 | MAPK1 (0.37) | MAPK1 | |
| SCHEMBL13509577 | 0.73 | TSHR (0.46) | MAPK1 | |
| SCHEMBL3628274 | 0.71 | MAPK1 (0.39) | MAPK1 | |
| SCHEMBL25848205 | 0.71 | CA12 (0.46) | — | |
| SCHEMBL23337044 | 0.70 | — | — | |
| SCHEMBL19577450 | 0.70 | CA12 (0.48) | — | |
| SCHEMBL12744865 | 0.69 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL13652189 | 0.69 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL19191573 | 0.67 | MAOA (0.37) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359542-B1 | SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-17 | — | — | EP | disclosed |