SCHEMBL23099072 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	CSF1R	P07333	1/20	0.39

▸	ALDH1A1	P00352	2/20	0.37

▸	SMN1; SMN2	Q16637	1/20	0.36

▸	BDKRB2	P30411	2/20	0.35

▸	NPBWR1	P48145	1/20	0.34

▸	PRMT5	O14744	1/20	0.34

▸	WDR77	Q9BQA1	1/20	0.34

▸	SLC22A12	Q96S37	1/20	0.33

▸	KMT2A	Q03164	1/20	0.33

▸	MAPT	P10636	1/20	0.33

▸	NPSR1	Q6W5P4	1/20	0.33

▸	MAPK14	Q16539	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23087249	0.83	CSF1R (0.36)	CSF1RALDH1A1SMN1; SMN2PRMT5WDR77
SCHEMBL23087786	0.80	PRMT5 (0.48)	CSF1RALDH1A1SMN1; SMN2PRMT5WDR77
SCHEMBL29735294	0.80	PRMT5 (0.48)	CSF1RALDH1A1SMN1; SMN2PRMT5WDR77
SCHEMBL23099062	0.78	NOTUM (0.42)	PRMT5WDR77KMT2A
SCHEMBL23087744	0.75	PRMT5 (0.51)	PRMT5WDR77KMT2AMAPTNPSR1
SCHEMBL23087293	0.73	HTR2A (0.49)	SMN1; SMN2PRMT5WDR77
SCHEMBL23087256	0.73	PRMT5 (0.45)	ALDH1A1SMN1; SMN2PRMT5WDR77MAPT
SCHEMBL23087883	0.67	ALKBH1 (0.43)	ALDH1A1SMN1; SMN2NPBWR1KMT2AMAPK14
SCHEMBL12016024	0.66	SMN1; SMN2 (0.39)	SMN1; SMN2NPBWR1KMT2AMAPT
SCHEMBL19098911	0.66	SMN1; SMN2 (0.36)	SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021050915-A1	MTA-COOPERATIVE PRMT5 INHIBITORS	Mirati Therapeutics, Inc. (US)	2021-03-18	—	—	WO	disclosed