Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FABP1 | P07148 | 1/20 | 0.50 |
| ▸ | UQCRB | P14927 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10093392 | 1.00 | POLB (0.51) | POLBFABP1UQCRBHDAC3HDAC4 | |
| SCHEMBL10093369 | 0.87 | HSD17B2 (0.56) | UQCRBALOX12IKBKBGAAHPGD | |
| SCHEMBL10093389 | 0.84 | POLB (0.54) | POLBFABP1UQCRBHDAC3HDAC4 | |
| SCHEMBL2241347 | 0.84 | AVPR2 (0.43) | POLBALOX12ALDH1A1 | |
| SCHEMBL10093354 | 0.84 | CYP19A1 (0.50) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2309039 | 0.84 | FABP1 (0.49) | POLBFABP1UQCRBHDAC3HDAC4 | |
| SCHEMBL2235893 | 0.84 | AVPR2 (0.43) | POLBALOX12ALDH1A1 | |
| SCHEMBL2238392 | 0.84 | AVPR2 (0.43) | POLBALOX12ALDH1A1 | |
| SCHEMBL10093378 | 0.82 | GPR27 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10093381 | 0.81 | CYP19A1 (0.44) | KDM1AGAAHPGDMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-A1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | Pimco 2664 Limited (GB) | 2011-08-03 | — | — | EP | disclosed |