Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23879757 | 0.94 | KDM4E (0.38) | GAAMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL24877693 | 0.92 | GAA (0.38) | GAAMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL22327368 | 0.91 | GAA (0.43) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL22327386 | 0.91 | NR1H4 (0.41) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL23502901 | 0.90 | GAA (0.36) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL23879737 | 0.89 | GAA (0.35) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL22327367 | 0.88 | GAA (0.48) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL23957822 | 0.88 | GAA (0.43) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL24877167 | 0.87 | ALDH1A1 (0.38) | GAAMAPTKMT2AADRB2ADRB1 | |
| SCHEMBL23106232 | 0.87 | SMN1; SMN2 (0.37) | GAAMAPTKMT2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227798-A1 | MODIFIED THERMOCCOCUS POLYMERASES | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-07-20 | — | — | US | disclosed |
| US-20220119780-A1 | ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF | FIRST-CITIZENS BANK & TRUST COMPANY | 2022-04-21 | — | — | US | disclosed |
| US-20220119779-A1 | MODIFIED PYROCOCCUS POLYMERASES AND USES THEREOF | FIRST-CITIZENS BANK & TRUST COMPANY | 2022-04-21 | — | — | US | disclosed |
| US-11136565-B2 | Modified archaeal family B polymerases | Singular Genomics Systems, Inc. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20210284975-A1 | MODIFIED PYROCOCCUS POLYMERASES AND USES THEREOF | FIRST-CITIZENS BANK & TRUST COMPANY | 2021-09-16 | — | — | US | disclosed |
| US-20210079364-A1 | MODIFIED THERMOCCOCUS POLYMERASES | FIRST-CITIZENS BANK & TRUST COMPANY | 2021-03-18 | — | — | US | disclosed |